neuronal apoptosis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0853	Adenosine	D-Adenosine,Adenine riboside	Apoptosis , Nucleoside Antimetabolite/Analog , Endogenous Metabolite , Autophagy
	Adenosine (D-Adenosine) is a ribonucleoside comprised of adenine bound to ribose, with vasodilatory, antiarrhythmic and analgesic activities.
T5827	BI-6C9		Apoptosis , Others , Mitochondrial Metabolism
	BI-6C9 is an inhibitor of tBid (Kd = 20 µM).BI-6c9 prevented MOMP and mitochondrial fission, and protected the cells from cell death.		Apoptosis , Others , Mitochondrial Metabolism
T11571	HLY78	4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine	Wnt/beta-catenin
	HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) targets the DIX domain of Axin, is an activator of the Wnt/β-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling.		Wnt/beta-catenin
T1567	Olanzapine	LY170053	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , AChR
	Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
TN6714	Geranylgeraniol	FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,CJ-24095	Apoptosis
	Geranylgeraniol (FT0626663) is an isoprenoid found in fruits, vegetables, and grains, including rice. Geranylgeraniol (FT0626663) inhibits growth and induces apoptosis of various tumor cells. Geranylgeraniol (FT0626663) ...		Apoptosis
T0499	Oxybenzone	KAHSCREEN BZ-3,Benzophenone 3,Eusolex 4360,Escalol 567	Apoptosis , Retinoid Receptor , Autophagy
	Oxybenzone (Eusolex 4360) is an organic compound used in sunscreens. It is a derivative of benzophenone.		Apoptosis , Retinoid Receptor , Autophagy
T25450	GGTI 2147	GGTI2147,Geranylgeranyl transferase inhibitor-2147,GGTI-2147	NF-κB , Rho
	GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.		NF-κB , Rho
T39030	HBDDE		Apoptosis , PKC
	HBDDE is a selective model inhibitor of the isoenzymes PKCα and PKCγ with IC 50 s of 43 μM and 50 μM, respectively.HBDDE has a higher affinity for PKCα/PKCγ than the PKCδ, PKCβI, and PKCβII isoenzymes.HBDDE is a derivati...		Apoptosis , PKC
T5S0733	Picroside III		Others
	Picroside III, an iridoid glucoside found in the root of Picrorhiza scrophulariiflora Pennell (Scrophulariaceae), and its subtype Picroside II has been demonstrated to reduce apoptosis in neuronal cells and other cell ty...		Others
T24905	TT01001	TT-01001,TT 01001,Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate	Mitochondrial Metabolism
	TT01001 (Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate) is a selective agonist of mitoNEET and reduces oxidative stress injury and neuronal apoptosis by improving mitochondrial dysfunction. TT01001 c...		Mitochondrial Metabolism
T8852	Tubuloside B		Apoptosis , Others
	The neuroprotective effect of tubuloside B, one of the phenylethanoids isolated from the stems of Cistanche salsa, on tumor necrosis factor-alpha (TNFalpha)-induced apoptosis in SH-SY5Y neuronal cells.		Apoptosis , Others
T9138	Indirubin-3′-oxime	Indirubin-3'-monoxime	GSK-3 , CDK , JNK
	Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.		GSK-3 , CDK , JNK
T64353	4-tert-Octylphenol		Endogenous Metabolite
	4-tert-Octylphenol, an endocrine-disrupting chemical with estrogenic properties, notably induces apoptosis in offspring mouse brain neuronal progenitor cells. This compound decreases levels of bromodeoxyuridine (BrdU), m...		Endogenous Metabolite
T3902	Atractylenolide III	ICodonolactone,8β-Hydroxyasterolide	Apoptosis
	Atractylenolide III (ICodonolactone) may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury. Atractylenolide III is a potential candidate for the treatment of human lung...		Apoptosis
T3637	Pifithrin-β hydrobromide	Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)	Ferroptosis , p53
	Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorder...		Ferroptosis , p53
T23709	AlphaSYN-IN-NAB2	alphaSYN inhibitor NAB2,alphaSYNINNAB2,alphaSYN-IN-NAB2,NAB2,alphaSYN inhibitor-NAB2
	alphaSYN-IN-NAB2, a neuron-protective agent, is a protein encoded by the NAB2 gene. NAB2 effectively and selectively protects a variety of cells from alpha-SYN toxicity. NAB2 promotes endosomal transport dependent on E3 ...
T35689	MTP 131 acetate		Others
	MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging...		Others
T4S0823	Astragaloside		Others
	Astragaloside may protect against brain contusion and neuronal apoptosis after TBI by attenuating microglia activation in male rats. Astragalosides-induced apoptosis in NB4 cells may be associated with down-regulation of...		Others
T71852	Lig4-4
	Lig4-4 is a TREK-1 current inhibitor (IC50 = 2.06 μM) that has demonstrated potential for use as a protective agent against cerebral ischemia. It has been postulated that the neuroprotective effects of Lig4-4 against cer...
T37162	8-hydroxy Efavirenz
	8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz . 8-hydroxy Efavirenz is formed when efavirenz is metabolized by the cytochrome P450 (CYP) isoform CYP2B...